Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinoma

@inproceedings{Yamasaki2011RoleOM,
  title={Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinoma},
  author={Makoto Yamasaki and Tomonori Makino and Toru Masuzawa and Yukinori Kurokawa and Hiroshi Miyata and Shuji Takiguchi and Kiyokazu Nakajima and Yuichiro Fujiwara and Noriko Matsuura and Miwa Mori and Yuichiro Doki},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:Although multidrug resistance protein 2 (MRP2) confers chemoresistance in some cancer types, its implication on oesophageal squamous cell carcinoma (ESCC) remains unclear.Methods:We evaluated MRP2 expression by immunohistochemistry and RT–PCR using 81 resected specimens from ESCC patients who did or did not receive neo-adjuvant chemotherapy (NACT), including 5-fluorouracil, doxorubicin, and cisplatin (CDDP). Correlation between MRP2 expression and response to chemotherapy was also… CONTINUE READING

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