Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.

@article{Ferslew2014RoleOM,
  title={Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.},
  author={Brian C. Ferslew and Kathleen Koeck and Arlene S. Bridges and Kim L R Brouwer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 9},
  pages={1567-74}
}
Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administration, enalapril is converted to enalaprilat in hepatocytes and undergoes translocation into the systemic circulation to exert its pharmacologic effect by inhibiting angiotensin-converting enzyme. Although the transport proteins governing hepatic uptake of enalapril and the biliary excretion of… CONTINUE READING