Role of moving growth cone-like "wave" structures in the outgrowth of cultured hippocampal axons and dendrites.

@article{Ruthel1999RoleOM,
  title={Role of moving growth cone-like "wave" structures in the outgrowth of cultured hippocampal axons and dendrites.},
  author={Gordon Ruthel and Gary Banker},
  journal={Journal of neurobiology},
  year={1999},
  volume={39 1},
  pages={97-106}
}
Hippocampal neurons exhibit periodically recurring growth cone-like structures, referred to as "waves," that emerge at the base of neurites and travel distally to the tip. As a wave nears the tip, the neurite undergoes retraction, and when it reaches the tip, the neurite undergoes a burst of growth. At 1 day in culture, during early axon outgrowth, axons undergo an average 7.5-microm retraction immediately preceding wave arrival at the tip followed by 12-microm growth immediately after arrival… CONTINUE READING

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