Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway.

@article{Nilwarangkoon2007RoleOM,
  title={Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway.},
  author={Sirinun Nilwarangkoon and Naohiko Anzai and Katsuko Shiraya and Erkang Yu and Rafiqul Islam and Seok Ho Cha and Maristela Lika Onozato and Daisaku Miura and Promsuk Jutabha and Akihiro Tojo and Yoshikatsu Kanai and Hitoshi Endou},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={103 1},
  pages={48-55}
}
Renal organic anion transporters play an important role in the handling of a number of endogenous and exogenous anionic substances in the kidney. In this study, we investigated prostaglandin E(2) (PGE(2)) transport properties and intrarenal localization of mouse organic anion transporter 3 (mOat3). When expressed in Xenopus oocytes, mOat3 mediated the time- and concentration-dependent transport of PGE(2) (K(m): 1.48 microM). PGE(2) transport mediated by mOat3 was trans-stimulated by… CONTINUE READING

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