Role of monomeric activators in cobra venom phospholipase A2 action.

Abstract

Phospholipase A2 from cobra venom (Naja naja naja), which acts poorly on phosphatidylethanolamine (PE) in mixed micelles, is activated toward PE by the monomeric phospholipid dibutyrylphosphatidylcholine (dibutyryl-PC) which is an, even poorer substrate. Phosphorus-31 nuclear magnetic resonance spectroscopy was employed to show that only PE is hydrolyzed in… (More)

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