Role of monocytes in atherogenesis.

  title={Role of monocytes in atherogenesis.},
  author={Bjarne Osterud and Eirik Bjorklid},
  journal={Physiological reviews},
  volume={83 4},
This review focuses on the role of monocytes in the early phase of atherogenesis, before foam cell formation. An emerging consensus underscores the importance of the cellular inflammatory system in atherogenesis. Initiation of the process apparently hinges on accumulating low-density lipoproteins (LDL) undergoing oxidation and glycation, providing stimuli for the release of monocyte attracting chemokines and for the upregulation of endothelial adhesive molecules. These conditions favor monocyte… CONTINUE READING

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