Role of monocarboxylate transporters in human cancers: state of the art.

@article{Pinheiro2012RoleOM,
  title={Role of monocarboxylate transporters in human cancers: state of the art.},
  author={C{\'e}line Pinheiro and Adhemar Longatto-Filho and Jo{\~a}o Azevedo-Silva and Margarida Casal and F Schmitt and F{\'a}tima Baltazar},
  journal={Journal of bioenergetics and biomembranes},
  year={2012},
  volume={44 1},
  pages={127-39}
}
Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. The role of MCTs in cell homeostasis has been characterized in detail in normal tissues, however, their role in cancer is still far from understood. Most solid tumors are known to rely on glycolysis for energy production and this activity leads to production of important amounts… CONTINUE READING
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