Role of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad.

@article{Abe2000RoleOM,
  title={Role of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad.},
  author={Jun-ichi Abe and Christopher P. Baines and Bradford C. Berk},
  journal={Circulation research},
  year={2000},
  volume={86 6},
  pages={
          607-9
        }
}
There is growing evidence that multiple mitogen-activated protein (MAP) kinases are activated during ischemia and/or reperfusion and may contribute to the structural and functional changes after myocardial ischemia. A new study by Yue et al1 in this issue of Circulation Research attempts to address the role of MAP kinases in ischemic myocardium and suggests that ERK1/ERK2 is part of a “survival” pathway whereas p38 and JNK mediate a “death” pathway in the ischemic myocardium. Myocyte loss… CONTINUE READING

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