Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells.

@article{Lg2005RoleOM,
  title={Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells.},
  author={Marit L{\aa}g and Magne Refsnes and Edel Marie Lilleaas and J\orn A Holme and Rune Becher and Per Everhard Schwarze},
  journal={Toxicology},
  year={2005},
  volume={211 3},
  pages={253-64}
}
Cadmium acetate (CdAc) induced apoptosis in primary alveolar type 2 cells and Clara cells from rat lung. Phosphorylation of the MAPKs ERK1/2, p38 and JNK was markedly increased in both cell types 15 min to 2 h after start of exposure to 10 microM CdAc. The phosphorylation of all the MAPKs remained elevated or was progressively increased up to 12 h. The p38 inhibitor SB202190 reduced the Cd-induced apoptosis, whereas the ERK and JNK inhibitors, PD98059 and JNKI1, respectively, did not have any… CONTINUE READING
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