Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium

@inproceedings{Zinovkin2014RoleOM,
  title={Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium},
  author={Roman A Zinovkin and Valeria P. Romaschenko and Ivan I. Galkin and Vlada V. Zakharova and Olga Yu Pletjushkina and Boris V Chernyak and Ekaterina N Popova},
  booktitle={Aging},
  year={2014}
}
Vascular aging is accompanied by increases in circulatory proinflammatory cytokines leading to inflammatory endothelial response implicated in early atherogenesis. To study the possible role of mitochondria-derived reactive oxygen species (ROS) in this phenomenon, we applied the effective mitochondria-targeted antioxidant SkQ1, the conjugate of plastoquinone with dodecyltriphenylphosphonium. Eight months treatment of (CBAxC57BL/6) F1 mice with SkQ1 did not prevent age-related elevation of the… CONTINUE READING
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Mitochondria ‐ Targeted Antioxidants Prevent TNFalpha ‐ Induced Endothelial

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