Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

  title={Role of mitochondrial homeostasis and dynamics in Alzheimer's disease},
  author={J Eva Selfridge and E Lezi and Jianghua Lu and Russell Howard Swerdlow},
  journal={Neurobiology of Disease},
Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects a staggering percentage of the aging population and causes memory loss and cognitive decline. Mitochondrial abnormalities can be observed systemically and in brains of patients suffering from AD, and may account for part of the disease phenotype. In this review, we summarize some of the key findings that indicate mitochondrial dysfunction is present in AD-affected subjects, including cytochrome oxidase deficiency… CONTINUE READING


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