Role of mitochondrial dysfunction in insulin resistance.

  title={Role of mitochondrial dysfunction in insulin resistance.},
  author={J H Kim and Yongzhong Wei and James R. Sowers},
  journal={Circulation research},
  volume={102 4},
Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively contribute to a substantial risk for cardiovascular disease. Metabolic actions of insulin in classic insulin target tissues (eg, skeletal muscle, fat, and liver), as well as actions in nonclassic targets (eg, cardiovascular tissue), help to explain why insulin resistance and metabolic dysregulation are central in the… CONTINUE READING