Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release.

  title={Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release.},
  author={E D Kennedy and Claes B Wollheim},
  journal={Diabetes & metabolism},
  volume={24 1},
Glucose-stimulated insulin release from pancreatic beta cells involves a complex series of signalling pathways. In many forms of diabetes, lesions in this process cause or aggravate the diabetic phenotype. A common motif in these cascades is the elevation of intracellular Ca2+ both in the cytosolic compartment ([Ca2+]c) and within the mitochondria ([Ca2+]m). These parameters can be effectively monitored using the photoprotein aequorin which can be targeted to subcellular compartments by… CONTINUE READING
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