Role of mitochondrial amyloid-beta in Alzheimer's disease.

Abstract

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Abnormalities in mitochondrial properties include impaired energy metabolism, defects in key respiratory enzyme activity/function, accumulation/generation of mitochondrial reactive oxygen species, and formation of membrane permeability transition pore. While the mechanisms underlying… (More)
DOI: 10.3233/JAD-2010-100357

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