Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids.

@article{Bharathi2020RoleOM,
  title={Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids.},
  author={Sivakama S. Bharathi and Y. Zhang and Zhenwei Gong and Radhika H. Muzumdar and E. Goetzman},
  journal={Biochemical and biophysical research communications},
  year={2020},
  volume={527 1},
  pages={
          162-166
        }
}
  • Sivakama S. Bharathi, Y. Zhang, +2 authors E. Goetzman
  • Published 2020
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • Dicarboxylic fatty acids, taken as a nutritional supplement or produced endogenously via omega oxidation of monocarboxylic fatty acids, may have therapeutic potential for rare inborn errors of metabolism as well as common metabolic diseases such as type 2 diabetes. Breakdown of dicarboxylic acids yields acetyl-CoA and succinyl-CoA as products, the latter of which is anaplerotic for the TCA cycle. However, little is known about the metabolic pathways responsible for degradation of dicarboxylic… CONTINUE READING

    References

    SHOWING 1-10 OF 32 REFERENCES
    The microsomal dicarboxylyl-CoA synthetase.
    • 68
    • PDF
    In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver.
    • 76
    Use of dicarboxylic acids in type 2 diabetes.
    • 27