Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression.

@article{MadsenBouterse2010RoleOM,
  title={Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression.},
  author={Sally A. Madsen-Bouterse and Ghulam Mohammad and Mamta Kanwar and Renu A Kowluru},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={13 6},
  pages={797-805}
}
Diabetic retinopathy does not halt after hyperglycemia is terminated; the retina continues to experience increased oxidative stress, suggesting a memory phenomenon. Mitochondrial DNA (mtDNA) is highly sensitive to oxidative damage. The goal is to investigate the role of mtDNA damage in the development of diabetic retinopathy, and in the metabolic memory. mtDNA damage and its functional consequences on electron transport chain (ETC) were analyzed in the retina from streptozotocin-diabetic rats… CONTINUE READING