Role of mitochondria in ultraviolet-induced oxidative stress.

@article{Gniadecki2000RoleOM,
  title={Role of mitochondria in ultraviolet-induced oxidative stress.},
  author={Robert Gniadecki and Tine Thorn and Jana Vi{\vc}anov{\'a} and Andreas Br\onden Petersen and Hans Christian Olsen Wulf},
  journal={Journal of cellular biochemistry},
  year={2000},
  volume={80 2},
  pages={216-22}
}
The biological effects of ultraviolet radiation (UV), such as DNA damage, mutagenesis, cellular aging, and carcinogenesis, are in part mediated by reactive oxygen species (ROS). The major intracellular ROS intermediate is hydrogen peroxide, which is synthesized from superoxide anion ((*)O(2)(-)) and further metabolized into the highly reactive hydroxyl radical. In this study, we examined the involvement of mitochondria in the UV-induced H(2)O(2) accumulation in a keratinocyte cell line HaCaT… CONTINUE READING

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