Role of mitochondria in toxic cell death.

@article{Robertson2002RoleOM,
  title={Role of mitochondria in toxic cell death.},
  author={John D. Robertson and Sten Orrenius},
  journal={Toxicology},
  year={2002},
  volume={181-182},
  pages={491-6}
}
Apoptosis is a highly regulated form of cell death distinguished by the activation of a family of cysteine-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. Abundant evidence supports a role for mitochondria in regulating apoptosis. Specifically, it seems that a number of death triggers target these organelles and stimulate, by an unknown mechanism, the release of several proteins, including… CONTINUE READING
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