Role of mitochondria in the regulation of hypoxia-inducible factor-1α in the rat carotid body glomus cells

@article{Baby2005RoleOM,
  title={Role of mitochondria in the regulation of hypoxia-inducible factor-1α in the rat carotid body glomus cells},
  author={Santhosh M. Baby and Arijit Roy and Sukhamay Lahiri},
  journal={Histochemistry and Cell Biology},
  year={2005},
  volume={124},
  pages={69-76}
}
Hypoxia-inducible factor-1α (HIF-1α) protein, a heterodimeric transcription factor that regulates transcriptional activation of several genes, is involved in adaptive responses to hypoxia. Earlier, we have reported that in carotid body (CB), the peripheral oxygen sensing organ, HIF-1α is up-regulated during hypoxia. One model proposes that an intact mitochondrial respiratory chain is necessary for this regulation of HIF-1α. To test this hypothesis in the CB glomus cells, we studied the effect… CONTINUE READING

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