Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells

@article{Kallio2005RoleOM,
  title={Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells},
  author={Anu Kallio and Aiping Zheng and Johanna Dahllund and Kaisa M. Heiskanen and Pirkko L. H{\"a}rk{\"o}nen},
  journal={Apoptosis},
  year={2005},
  volume={10},
  pages={1395-1410}
}
Tamoxifen (Tam) is widely used in chemotherapy of estrogen receptor-positive breast cancer. It inhibits proliferation and induces apoptosis of breast cancer cells by estrogen receptor-dependent modulation of gene expression, but recent reports have shown that Tam (especially at pharmacological concentrations) has also rapid nongenomic effects. Here we studied the mechanisms by which Tam exerts rapid effects on breast cancer cell viability. In serum-free medium 5–7 μM Tam induced death of MCF-7… CONTINUE READING
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