Role of mitochondria in steroidogenesis.

@article{Papadopoulos2012RoleOM,
  title={Role of mitochondria in steroidogenesis.},
  author={Vassilios Papadopoulos and Walter Miller},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  year={2012},
  volume={26 6},
  pages={771-90}
}
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes, notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate-limiting step in steroidogenesis which determines cellular steroidogenic capacity. Even before this step, the access of cholesterol to this enzyme system is both rate-limiting and the site of acute regulation via the steroidogenic acute regulatory protein (StAR) which interacts with a complex multi-component… CONTINUE READING

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