Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.


Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an adult onset characterized by loss of both upper and lower motor neurons. In ~10% of cases, patients developed ALS with an apparent genetic linkage (familial ALS or fALS). Approximately 20% of fALS displays mutations in the SOD1 gene encoding superoxide dismutase 1. There are… (More)
DOI: 10.1016/j.bbadis.2014.02.009

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