Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents

@article{Vernole2003RoleOM,
  title={Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents},
  author={P. Vernole and R. Pepponi and S. D'atri},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2003},
  volume={52},
  pages={185-192}
}
  • P. Vernole, R. Pepponi, S. D'atri
  • Published 2003
  • Biology, Medicine
  • Cancer Chemotherapy and Pharmacology
  • PurposeThe mismatch repair (MMR) system plays a major role in mediating the cytotoxicity and clastogenicity of agents generating O6-methylguanine in DNA. Loss of MMR has also been associated with tumor cell resistance to the cytotoxic effects of 6-thioguanine and cisplatin and with hypersensitivity to N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea (CCNU). The aim of the present investigation was to elucidate the role played by the MMR system in the generation of chromosomal damage in cells… CONTINUE READING

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