Role of mineralocorticoid receptors on the hypothalamus–pituitary–adrenal axis in humans

@article{Berardelli2012RoleOM,
  title={Role of mineralocorticoid receptors on the hypothalamus–pituitary–adrenal axis in humans},
  author={Rita Berardelli and Ioannis Karamouzis and Valentina D’Angelo and Clizia Zichi and Beatrice Fussotto and Roberta Giordano and Ezio Ghigo and Emanuela Arvat},
  journal={Endocrine},
  year={2012},
  volume={43},
  pages={51-58}
}
This clinical review will summarize the available data regarding the role of mineralocorticoid receptors (MRs) on the hypothalamus–pituitary–adrenal (HPA) axis control in physiological and pathological conditions and in the memory processes involved in the control and appraisal of a stress event. MRs are predominantly expressed in the limbic structures, with the hippocampus being the main localization, although MRs are also found at the hypothalamic level. It is known that hyppocampal MRs… Expand
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TLDR
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TLDR
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Influence of chronic stress on brain corticosteroid receptors and HPA axis activity.
TLDR
Comparison of the dynamics of changes in plasma ACTH and corticosterone level with respective alterations in GR and MR in brain structures suggests that the buffering effect of repeated stress depends on the period of habituation to stress and the brain structure involved in regulation of these stress response. Expand
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