Role of midbrain periaqueductal gray P2X3 receptors in electroacupuncture-mediated endogenous pain modulatory systems.

@article{Xiao2010RoleOM,
  title={Role of midbrain periaqueductal gray P2X3 receptors in electroacupuncture-mediated endogenous pain modulatory systems.},
  author={Zhi Xiao and Shan Shan Ou and Wen-juan He and Yan-dong Zhao and Xiaohong Liu and Huai-zhen Ruan},
  journal={Brain research},
  year={2010},
  volume={1330},
  pages={31-44}
}
Extracellular ATP facilitates pain transmission at peripheral and spinal sites via the P2X receptors and the P2X3 subtype is an important candidate for this effect. Electroacupuncture (EA) has been clinically utilized to manage chronic pain. In this study, with neuropathic pain model of Sprague-Dawley (SD) rats, the P2X3 receptor protein level and expression location in the midbrain periaqueductal gray (PAG), a crucial site in endogenous pain modulatory system, were evaluated by Western… CONTINUE READING