Role of microphthalmia transcription factor (Mitf) in melanoma differentiation.

@article{Lekmine2007RoleOM,
  title={Role of microphthalmia transcription factor (Mitf) in melanoma differentiation.},
  author={Fatima Lekmine and Chih Kai Chang and Nan Sethakorn and Tapas K. Das Gupta and George I. Salti},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 3},
  pages={
          830-5
        }
}
We transfected the melanocyte-specific Mitf-M isoform into the aggressive melanoma UISO-Mel-6 cell lines. Our data show that Mitf decreases cell proliferation and results in cells which grow in clusters. By analyzing the expression of the markers of differentiation, we demonstrate that Mitf favored increased expression of tyrosinase and tyrosinase-related protein-1. In addition, Mitf induces Bcl-2 expression following transfection of UISO-Mel-6 cells. We also showed that Mitf gene affects cell… CONTINUE READING
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