Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

@article{Brown1996RoleOM,
  title={Role of microglia and host prion protein in neurotoxicity of a prion protein fragment},
  author={David R Brown and Bernhard M. W. Schmidt and Hans A. Kretzschmar},
  journal={Nature},
  year={1996},
  volume={380},
  pages={345-347}
}
THE prion protein PrPc is a glycoprotein of unknown function1 normally found in neurons2 and glia3. It is involved in diseases such as bovine spongiform encephalopathy (BSE), scrapie and Creutzfeldt–Jakob disease4. PrPSc, an altered isoform of PrPc that is associated with disease, shows greater protease resistance and is part of the infectious agent, the prion5,6. Prion diseases are characterized by neuronal degeneration, gliosis and accumulation of PrPSc (ref. 7). Mice devoid of PrPc are… CONTINUE READING
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