Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions.

@article{Cardoso2016RoleOM,
  title={Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions.},
  author={Ana Lu{\'i}sa Cardoso and Joana R Guedes and Maria C Pedroso de Lima},
  journal={Current opinion in pharmacology},
  year={2016},
  volume={26},
  pages={
          1-9
        }
}
MiRNAs are short, evolutionary conserved noncoding RNA molecules with the ability to control the magnitude of inflammation. The immunosuppressive nature of the brain is sustained by miRNA-dependent regulation of microglial cells, which become activated under neuroinflammatory conditions, such as brain injury and neurodegeneration. The pro-inflammatory and suppressive role of the most studied neuroimmune miRNAs, miR-155 and miR-146a, has been recently challenged. Although the molecular targets… CONTINUE READING
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