Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus

  title={Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus},
  author={Naoko Hashimoto and Tomoaki Tanaka},
  journal={Journal of Human Genetics},
MicroRNAs (miRNAs) are noncoding RNAs of ~22 nucleotides that regulate gene expression post-transcriptionally by binding to the 3′ untranslated region of messenger RNA (mRNAs), resulting in inhibition of translation or mRNA degradation. miRNAs have a key role in fine-tuning cellular functions such as proliferation, differentiation and apoptosis, and they are involved in carcinogenesis, glucose homeostasis, inflammation and other biological processes. In this review, we focus on the role of… CONTINUE READING
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