Role of miR-19a targeting TNF-α in mediating ulcerative colitis.

  title={Role of miR-19a targeting TNF-α in mediating ulcerative colitis.},
  author={Bingguang Chen and Shifeng She and Detang Li and Zhihui Liu and Xiaojun Yang and Zhirong Zeng and Fengbin Liu},
  journal={Scandinavian journal of gastroenterology},
  volume={48 7},
OBJECTIVE Ulcerative colitis (UC) is a widely studied inflammatory disease associated with differential expression of genes involved in immune function, wound healing, and tissue remodeling. MicroRNAs have been reported to play a role in various cancer types. However, the mechanism of how microRNAs regulate UC remains unclear. METHODS In the present study, we investigated the role of miR-19a and tumor necrosis factor (TNF)-α in human colon tissues with UC and dextran sodium sulfate (DSS… CONTINUE READING

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