Role of miR-155 in the regulation of lymphocyte immune function and disease.

@article{Seddiki2014RoleOM,
  title={Role of miR-155 in the regulation of lymphocyte immune function and disease.},
  author={Nabila Seddiki and Vedran Brezar and Nicolas Ruffin and Yves L{\'e}vy and Sanjay Swaminathan},
  journal={Immunology},
  year={2014},
  volume={142 1},
  pages={32-8}
}
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide… CONTINUE READING
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