Role of methionine sulfoxide reductases A and B of Enterococcus faecalis in oxidative stress and virulence.

@article{Zhao2010RoleOM,
  title={Role of methionine sulfoxide reductases A and B of Enterococcus faecalis in oxidative stress and virulence.},
  author={Chen Zhao and Axel Hartke and Marilena La Sorda and Brunella Posteraro and J R Laplace and Yanick Auffray and Maurizio Sanguinetti},
  journal={Infection and immunity},
  year={2010},
  volume={78 9},
  pages={3889-97}
}
Methionine sulfoxide reductases A and B are antioxidant repair enzymes that reduce the S- and R-diastereomers of methionine sulfoxides back to methionine, respectively. Enterococcus faecalis, an important nosocomial pathogen, has one msrA gene and one msrB gene situated in different parts of the chromosome. Promoters have been mapped and mutants have been constructed in two E. faecalis strains (strains JH2-2 and V583) and characterized. For both backgrounds, the mutants are more sensitive than… CONTINUE READING