Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes.

@article{ParmoCabaas2006RoleOM,
  title={Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes.},
  author={Marisa Parmo-Caba{\~n}as and Isabel Molina-Ortiz and Salom{\'o}n Mat{\'i}as-Rom{\'a}n and David Garc{\'i}a-Bernal and Xonia Carvajal-Vergara and Inmaculada Octavio del Valle and Atanasio Pandiella and Alicia G. Arroyo and Joaqu{\'i}n Teixid{\'o}},
  journal={The Journal of pathology},
  year={2006},
  volume={208 1},
  pages={108-18}
}
Malignant plasma cells in multiple myeloma home to the bone marrow (BM), accumulate in different niches and, in late disease, migrate from the BM into blood. These migratory events involve cell trafficking across extracellular matrix (ECM)-rich basement membranes and interstitial tissues. Metalloproteinases (MMP) degrade ECM and facilitate tumour cell invasion. The chemokine CXCL12 is expressed in the BM, and it was previously shown that it triggers myeloma cell migration and activation. In the… CONTINUE READING
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