Role of metal ions in the cognitive decline of Down syndrome

Abstract

Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer's disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid βpeptide deposition, the appearance of tau-containing neurofibrillary tangles and… (More)
DOI: 10.3389/fnagi.2014.00136

Topics

Cite this paper

@inproceedings{Malakooti2014RoleOM, title={Role of metal ions in the cognitive decline of Down syndrome}, author={Nakisa Malakooti and Melanie April Pritchard and Paul A. Adlard and David I Finkelstein}, booktitle={Front. Aging Neurosci.}, year={2014} }