Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.

@article{Suzuki2000RoleOM,
  title={Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.},
  author={Hodaka Suzuki and Yuichi Sugiyama},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2000},
  volume={12 1},
  pages={3-12}
}
It has been established that the absorption of many drugs from the small intestine is hindered by the detoxification systems which are present in this epithelial tissue. In this article, we will summarize the significant role of small intestine in reducing the oral bioavailability of drugs, particularly focusing on the role of metabolic enzymes and efflux transporters. Since the role of cytochrome P450 3A (CYP3A) and MDR1 P-glycoprotein (P-gp) in intestinal drug disposition has been highlighted… CONTINUE READING

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