Role of metabolic H 2 O 2 generation : Redox signalling and oxidative stress

Abstract

Hydrogen peroxide, the non-radical twoelectron reduction product of oxygen, is a normal aerobic metabolite occurring at about 10 nM intracellular concentration. In liver, it is produced at 50 nmol per min per gram of tissue, which is about 2 % of total oxygen uptake at steady-state. Metabolically generated H2O2 emerged from recent research as central hub in… (More)

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Cite this paper

@inproceedings{Sies2014RoleOM, title={Role of metabolic H 2 O 2 generation : Redox signalling and oxidative stress}, author={Helmut Sies}, year={2014} }