Role of mesenchymal cell death in lung remodeling after injury.

  title={Role of mesenchymal cell death in lung remodeling after injury.},
  author={Vitaly A. Polunovsky and Bingkun Chen and Craig A. Henke and Donna Snover and Chris H Wendt and David H. Ingbar and Peter B Bitterman},
  journal={The Journal of clinical investigation},
  volume={92 1},
Repair after acute lung injury requires elimination of granulation tissue from the alveolar airspace. We hypothesized that during lung repair, signals capable of inducing the death of the two principal cellular elements of granulation tissue, fibroblasts and endothelial cells, would be present at the air-lung interface. Bronchoalveolar lavage fluid obtained from patients during lung repair induced both fibroblast and endothelial cell death, while fluid obtained at the time of injury or from… CONTINUE READING


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