Role of mesangial expansion in the pathogenesis of diabetic nephropathy.

  title={Role of mesangial expansion in the pathogenesis of diabetic nephropathy.},
  author={Michele Dalla Vestra and Alois Saller and Michael G. Mauer and Paola Fioretto},
  journal={Journal of nephrology},
  volume={14 Suppl 4},
Glomerulopathy, characterized by thickening of the glomerular basement membrane (GBM) and mesangial expansion, is the most important renal structural change in type 1 diabetic patients with diabetic nephropathy. Morphological lesions develop concomitantly in the arterioles, tubules and interstitium. Mesangial fractional volume [Vv(mes/glom)], an estimate of mesangial expansion, is the structural parameter that best correlates with glomerular filtration rate (GFR) and it is also closely related… CONTINUE READING
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