Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process.

@article{Galdiero2010RoleOM,
  title={Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process.},
  author={Stefania Galdiero and Annarita Falanga and Giuseppe Vitiello and Mariateresa Vitiello and Carlo Pedone and Gerardino D'Errico and Massimiliano Galdiero},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1798 3},
  pages={579-91}
}
The entry of enveloped viruses involves attachment followed by close apposition of the viral and plasma membranes. Then, either on the cell surface or in an endocytotic vesicle, the two membranes fuse by an energetically unfavourable process requiring the destabilisation of membrane microenvironment in order to release the viral nucleocapsid into the cytoplasm. The core fusion machinery, conserved throughout the herpesvirus family, involves glycoprotein B (gB) and the non-covalently associated… CONTINUE READING
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