Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells.

@article{Rothbard2004RoleOM,
  title={Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells.},
  author={Jonathan B. Rothbard and Theodore C Jessop and Richard S Lewis and Bryce A Murray and Paul A Wender},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 31},
  pages={9506-7}
}
The results described herein support a mechanistic hypothesis for how guanidine-rich transporters attached to small cargos (MW ca. <3000) can migrate across the lipid membrane of a cell and directly enter the cytosol. Arginine oligomers are found to partition almost completely into the aqueous layer of a water-octanol bilayer. However, when the same partitioning experiment is conducted in the presence of sodium laurate, a representative negatively charged membrane constituent, the arginine… CONTINUE READING
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