Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells.

@article{BarillaLaBarca2002RoleOM,
  title={Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells.},
  author={Maria L. Barilla-LaBarca and M. Kathryn Liszewski and John D. Lambris and Dennis E. Hourcade and John P Atkinson},
  journal={Journal of immunology},
  year={2002},
  volume={168 12},
  pages={6298-304}
}
C4b and C3b deposited on host cells undergo limited proteolytic cleavage by regulatory proteins. Membrane cofactor protein (MCP; CD46), factor H, and C4b binding protein mediate this reaction, known as cofactor activity, that also requires the plasma serine protease factor I. To explore the roles of the fluid phase regulators vs those expressed on host cells, a model system was used examining complement fragments deposited on cells transfected with human MCP as assessed by FACS and Western… CONTINUE READING
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