Role of melatonin in the pathophysiology of migraine: implications for treatment.

@article{Vogler2006RoleOM,
  title={Role of melatonin in the pathophysiology of migraine: implications for treatment.},
  author={Barbara Vogler and Alan Mark Rapoport and Stewart J. Tepper and Fred D. Sheftell and Marcelo Eduardo Bigal},
  journal={CNS drugs},
  year={2006},
  volume={20 5},
  pages={343-50}
}
The pineal gland and its secretory product, melatonin, have been implicated in the pathophysiology of migraine, as well as some of its comorbid disorders. Supporting this view, many migraineurs are susceptible to various environmental triggers that influence the secretion of melatonin from the pineal gland, and many prodromal symptoms are probably generated in the hypothalamus, a brain region that provides input into the pineal gland to modulate the secretion of melatonin. In addition, studies… CONTINUE READING