Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

@article{Lee2004RoleOM,
  title={Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.},
  author={S G Lee and Kiyoshi Tsuji and S Lee and Eng H. Lo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 3},
  pages={671-8}
}
Mechanisms of selective neuronal death in the hippocampus after global cerebral ischemia remain to be clarified. Here, we explored a possible role for matrix metalloproteinases (MMPs) in this phenomenon. Although many studies have demonstrated detrimental roles for the gelatinase MMP-9 in focal cerebral ischemia, how dysregulated MMP proteolysis influences global cerebral ischemia is less well understood. In this study, CD-1 mice were subjected to transient global ischemia. Transient occlusions… CONTINUE READING
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