Role of matrix metalloproteinases in colorectal carcinogenesis.

  title={Role of matrix metalloproteinases in colorectal carcinogenesis.},
  author={Martin J. Heslin and J Yan and Malisha R Johnson and Heidi Weiss and Robert B. Diasio and Marshall M. Urist},
  journal={Annals of surgery},
  volume={233 6},
OBJECTIVE To measure coexpression of matrix metalloproteinase (MMP)-2, MMP-7, and MMP-9 genes by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) in benign and malignant phases of colorectal carcinogenesis. SUMMARY BACKGROUND DATA Matrix metalloproteinases degrade and remodel the extracellular matrix and have been implicated in facilitating carcinoma cells to invade and metastasize. MMP-2, MMP-7, and MMP-9 have been shown to be overexpressed in various… CONTINUE READING