Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi.

@article{Castillo2012RoleOM,
  title={Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi.},
  author={Christian Castillo and Rodrigo A. L{\'o}pez-Mu{\~n}oz and Juan Duaso and Norbel Galanti and Fabi{\'a}n Ja{\~n}a and Jos{\'e} Pedro Areosa Ferreira and Gonzalo Cabrera and Juan D Maya and Ulrike Kemmerling},
  journal={Placenta},
  year={2012},
  volume={33 12},
  pages={991-7}
}
BACKGROUND Chagas' disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier. In the present study we analyzed the participation of matrix metalloproteases (MMPs) in the extracellular matrix (ECM) remodeling during T. cruzi ex vivo infection of human placental chorionic villi explants. METHODS Chorionic villi from healthy woman placentas were incubated in the presence or absence of 10⁵ or 10… CONTINUE READING
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