Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.

@article{Lee2002RoleOM,
  title={Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.},
  author={Sujin Lee and Mei Zheng and Bumseok Kim and Barry T Rouse},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 8},
  pages={1105-11}
}
In this report, we demonstrate that herpes simplex virus (HSV) infection of the cornea results in the upregulation of the matrix-degrading metalloproteinase enzyme MMP-9. This enzyme was shown to contribute to the neovascularization process that occurs in the corneal stroma in response to HSV infection. The likely source of MMP-9, at least initially after infection, was neutrophils that were signaled to invade the cornea soon after infection. Corneal infiltrating neutrophils were shown to… CONTINUE READING
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