Role of matriptase-2 (TMPRSS6) in iron metabolism.

  title={Role of matriptase-2 (TMPRSS6) in iron metabolism.},
  author={Pauline L. Lee},
  journal={Acta haematologica},
  volume={122 2-3},
Iron, an essential element for life, is regulated primarily at the level of uptake, storage, and transport in order to maintain sufficient availability for normal physiology. The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron in the circulation by binding and promoting the degradation of the iron exporter ferroportin. Given the central importance of hepcidin, recent studies have focused on how iron is sensed and how the iron signal is… CONTINUE READING


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