Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells

@article{Kattan2007RoleOM,
  title={Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells},
  author={Zilal Kattan and Vanessa Minig and Pierre Leroy and Michel Dauça and Philippe Becuwe},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={108},
  pages={203-215}
}
Manganese superoxide dismutase (MnSOD) is known to play a role in cancer. MnSOD exerts a tumor suppressive effect in estrogen-dependent human breast cancer cells. In the present study we investigated the in vitro role of MnSOD in the growth of some aggressive and highly metastatic estrogen-independent breast cancer cells, i.e., MDA-MB231 and SKBR3 cells. We show that estrogen-independent cells expressed a significantly higher basal MnSOD level compared to estrogen-dependent human breast cancer… CONTINUE READING
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