Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes.

@article{Hislop2004RoleOM,
  title={Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes.},
  author={James N. Hislop and Aaron Marley and Mark von Zastrow},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 21},
  pages={
          22522-31
        }
}
Many signaling receptors require covalent modification by ubiquitin for agonist-induced down-regulation via endocytic trafficking to lysosomes, a process that is mediated by a conserved set of endosome-associating proteins also required for vacuolar protein-sorting (VPS) in yeast. The delta opioid receptor (DOR) is a G protein-coupled receptor that can undergo agonist-induced proteolysis via endocytic trafficking to lysosomes but does not require covalent modification by ubiquitin to do so… CONTINUE READING
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Mechanism of Opioid Receptor Sorting to Lysosomes

G. O. Tanzi, A. J. Piefer, P. Bates
J. Virol • 2003
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