Role of mammalian Rad54 in telomere length maintenance.

@article{Jaco2003RoleOM,
  title={Role of mammalian Rad54 in telomere length maintenance.},
  author={Isabel Jaco and Purificaci{\'o}n Mu{\~n}oz and Ferm{\'i}n A. Goytisolo and Joanna Wesoly and Susan Bailey and Guillermo E. Taccioli and Maria A Blasco},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 16},
  pages={5572-80}
}
The homologous recombination (HR) DNA repair pathway participates in telomere length maintenance in yeast but its putative role at mammalian telomeres is unknown. Mammalian Rad54 is part of the HR machinery, and Rad54-deficient mice show a reduced HR capability. Here, we show that Rad54-deficient mice also show significantly shorter telomeres than wild-type controls, indicating that Rad54 activity plays an essential role in telomere length maintenance in mammals. Rad54 deficiency also resulted… CONTINUE READING

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